Compounds and methods for degradation improve target protein

The present invention is useful bifunctional compounds as modulators of the targeted ubiquitination, in particular, the various polypeptides and other proteins that are inhibited by the decomposed and / or otherwise by bifunctional compounds of the present invention regarding useful bifunctional compounds as inhibitors. In particular, the present invention, as the protein in order to perform the decomposition of the target protein (and inhibition) are disposed in proximity to the ubiquitin ligase includes a VHL ligand binding to ubiquitin ligase at one end, binding to the target protein It includes a portion on the other end, to a compound. The present invention is consistent with the decomposition / inhibition of the targeting polypeptides, exhibit a wide range of pharmacological activity associated with the compounds of the present invention.