Gut hormones regulating Apetite

Obesity is a global health crisis resulting in major morbidity and premature death. The obesity epidemic has been recognized by the World Health Organization (WHO) as one of the top 10 global health problems. No currently available medical therapy delivers substantial, sustainable weight loss. Over the last 20 years, peptide hormones released from the gastrointestinal tract in response to nutritional stimuli have come to be recognized as important physiological regulators of appetite. Hormones such as peptide YY, pancreatic polypeptide, glucagon-like peptide-1 and Oxyntomodulin are thought to act as postprandial satiety signals. Here, we review the state of current knowledge of these hormones for future research and development.