Influence of pH on the UV sensitivity of peritoneal macrophage plasma membrane
2010
Lowering the extracellular pH (from 7.2 to 6.3) or intracellular acidification in isolated murine peritoneal macrophages before UV-irradiating them to 9 J/cm2 (λmax = 306 nm) diminish the percentage of cells with damaged membranes. Extracellular pH 8.4 or intracellular alkalization have an opposite effect. After transient hypoosmotic swelling, the UV-induced membrane damage is fully pronounced regardless of external pH. In cells that survive UV-irradiation to 8 and 10 J/cm2 (λmax = 297 nm), the intracellular pH is 0.2 and 0.25 unit lower than in nonirradiated cells.
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