Near-triploid acute lymphoblastic leukemia with TEL/AML1 translocation.

An 11-year-old girl was diagnosed as B-precursor acute lymphoblastic leidemia (ALL) with co-expression of myeloid antigens. Cytogenetic analysis revealed a near-triploid (75-82 chromosomes/cell) abnormal chromosomal complement. Fluroscent in situ hybridization studies indicated presence of TEL/AMLI fusion genes. We discuss the prognostic relevance of TEL/AMLI in this rare near-triploid subtype of ALL.