Response to “A Simplified Implementation of the Bubble Analysis of Biopolymer Networks Pores”

In their comment in this issue of the Biophysical Journal, Munster and Fabry (1) propose a simple and elegant implementation of our bubble method (2) based on the Euclidean distance map (EDM) (3). This EDM bubble method is quite efficient in boosting the performance of our original method because it is fast and at the same time provides the optimal (maximal) coverage of the image, ensuring high accuracy in the parameters recovery (3). Thus, the implementation proposed by Munster and Fabry (1) appears to overcome simultaneously the main two limitations of our original method.