The effectiveness of Aloe vera peel extract on the reproductive status of streptozotocin-induced diabetic rats

Diabetes mellitus is a disorder in glucose metabolism that can cause complications in the reproductive organs. Aloe vera is a medicinal plant that has been widely used as an antidiabetic. The research objective was to analyze Aloe vera peel extract's effect on motility, sperm concentration, and testosterone levels in diabetic rats. The study design was a post-test-only randomized control group design consisting of a diabetes control group (DM) and a group with peel extract at a dose of 200 mg (PE1) and 400 mg/kg body weight (PE2) for 4 weeks. Rats were diabetic with glucose levels > 200 mg/dl after 72 hours of induction of streptozotocin 65 mg/kg BW. Data in the form of motility, sperm concentration, and testosterone levels were analyzed using ANOVA and LSD tests. The results showed a significant increase in the motility of the PEI and PE2 groups compared to DM. Testosterone concentrations and levels were significantly increased in the PE1 and PE2 groups compared to controls. The conclusion that can be stated is that the peel extract of Aloe vera can increase motility, sperm concentration, and testosterone levels of diabetic rats.