Клиническая оценка нарушений структурно-метаболического статуса эритроцитов периферической крови при дисплазии соединительной ткани у детей

As a result of a screening examination of 482 schoolchildren aged 7 to 12 years there were established that 18% children had connective tissue dysplasia (CTD) phenes. Structural and metabolic status of peripheral blood erythrocytes was studied in 51 children with CTD. There were revealed modifications superficial architectonics of red cells, decreased thiol groups and lipoproteins, increased content of diene conjugates and antioxidant activity. Degree of manifestation of CTD clinical signs correlated with structural and metabolic abnormalities of erythrocytes, increased lipid oxidative processes.