Effects of Serum Containing Belamcanda chinensis Extract on the Contraction of Isolated Guinea-pig Tracheal Smooth Muscle

Objective:To investigate the effects of Belamcanda chinensis extract on the contraction of isolated guinea-pig tracheal smooth muscle by serum pharmacological method.Method: The guinea-pig tracheal smooth muscle was isolated in the Kreb's solution,and its contraction was induced by histamine(His).The inhibitory effects of serum-containing drug on contraction of isolated tracheal strips were observed,and the constriction rate was calculated in 3,5,10 minute.Result: The serum-containing drug could significantly inhibit the contraction of the guinea-pig tracheal smooth muscle induced by His,in the dose 0.46 g·kg-1 group in 3,5,10 min antispasmodic rate was 44.29%,45.27%,48.30%;high dose(0.92 g·kg-1) in 3,5 min antispasmodic rate was 31.17% and 31.83%,compared with the control group there was a significant difference(P0.05 or P0.01),and the effects were better in 5 minute.Conclusion: The B.Chinensis extract has inhibitory effect on contraction of tracheal smooth muscle induced by His.