PP177. The usefulness of gestation-corrected hyperuricemia as a predictor of the development of preeclampsia on subsequent pregnancy.

Introduction Hyperuricemia has been described commonly in preeclamptic pregnancies, often preceding the diagnosis of preeclampsia and historically was used as a diagnostic marker of preeclampsia. Objectives The aim of this study was to determine the usefulness of uric acid to predict the preeclampsia on subsequent pregnancy. Methods The retrospective chart review was done. The pregnant women who had previous preeclampia or gestational hypertension and checked serum uric acid were enrolled in this study. Fifty-eight women were collected. Hyperuricemia was defined as being one standard deviation above the gestation-specific mean . And we used uric acid z -scores ([serum uric acid value – gestation specific mean]/standard deviation of the population) to account for gestation-specific alterations in uric acid and tested this as a continuous variable. Linear regression analysis was used to assess the relationship between gestation-corrected hyperuricemia and development of preeclampsia on subsequent pregnancy. Results Of 58 women, nineteen had the development of recurrent preeclampsia (37.5%). Linear regression analysis showed that the absence or presence of gestation-corrected hyperuricemia was not associated with the development of preeclampsia on subsequent pregnancy ( p  = 0.353, 95% CI 0.418–11.520). And gestation-specific uric acid z -score as a continuous variable did not show any association with the prediction of preeclampsia on subsequent pregnancy ( p  = 0.353, 95% CI 0.087–2.394). Conclusion Gestation-corrected hyperuricemia does not predict the development of preeclampsia on subsequent pregnancy.