골조직 재생을 위한 마이크로 기둥 패턴의 3 차원 생체적합 구조체 개발

To achieve successful bone tissue regeneration, various attempts have been tried to fabricate novel scaffolds which provide a proper environment for cells growth. Recently, solid freeform fabrication (SFF) technologies were in the spotlight as a way of controlling scaffold architecture such as pore size, porosity and inner/outer geometry. In this study, an NSTL (nano-stereolithography) system, one of the SFF technologies, was utilized to fabricate a novel structure which affects pre-osteoblast cell adhesion by offering micron-scaled pillar pattern on every layer. As pre-osteoblast cells were seeded on the pillar patterned surface, the cells had a tendency to migrate actively towards the adjacent pillars. As a result of patterned surface, the cell behaviors were shown with activated performance after 1day incubation. In conclusions, the scaffold with micro-pillar pattern on each layer has great potential for improving cell adhesion, compared to normal scaffold with flat surface.