Effect of Implanting Sustained-release 5-Fluorouracil in Operation on Local Recurrence of Liver Cancer

Objective To evaluate the effect of a local chemotherapy with sustained-release 5-fluorouracil during operation.Methods 63 patients diagnosed with Liver Cancer were devided into two groups: I(n=32), ordinary chemotherapy group, patients with conventional chemotherapy after operation; II(n=31), patients with sustained-release 5-fluorouracil in operation. The two groups of patients were follow-up a year, observe the reaction, disease and mortality from cancer patients.Results The two groups patients’liver function were no difference before operation(P0.05). The II group’s ALT、AST、TBL、PT、AFP were much lower than I group(P0.05);The transfer rate of group II was much lower than group I (P0.05);The incidence and mortality of group II were much lower than group I (P0.05).Conclusion The treatment of sustained-release 5-fluorouracil during operation can effectively reduce the transfer rate, recurrence and mortality of liver cancer patients, increase the patients’compliance and tolerance, it may be a new therapy for patients with liver cancer after hepatectomy.