New brain reperfusion rehabilitation therapy improves cognitive impairment in mild Alzheimer’s disease: a prospective, controlled, open-label 12-month study with NIRS correlates

Background and aims A large body of evidence indicates that cerebral hypoperfusion is one of the earliest signs in the development of Alzheimer’s disease (AD). The aim of our study was to evaluate whether the brain reperfusion rehabilitation therapy (BRRT) would improve verbal memory and learning and/or global cognitive impairment in mild AD.