Resveratrol and organic selenium-rich fermented milk reduce D-galactose-induced cognitive dysfunction in mice

Recently, dietary intervention has been considered as a prospective strategy in treating age-related cognitive dysfunction and brain plasticity degeneration. This study developed one kind of functional fermented milk rich in resveratrol and organic selenium, and explored the effect on cognitive behavior, hippocampal neurogenesis and the neurotrophic signaling pathway in D-galactose model mice. Behavioral tests showed that functional fermented milk significantly reversed spatial memory loss, and a recognition behavior reduction in a novel object recognition task. Immunohistochemistry analysis demonstrated that functional fermented milk significantly increased the hippocampal neurogenesis. Moreover, walnut diets with the dairy products reserved a D-galactose induced decrease of hippocampal p-ERK/ERK, p-CREB/CREB, and BDNF expression in the protein levels. These findings confirmed that dietary treatment with the functional fermented milk could ameliorate cognitive dysfunction in D-galactose model mouse, and yoghurt rich in resveratrol and organic selenium has the potential in treating the age-related diseases.