Heterogeneous bimetallic Au–Co nanoparticles as new efficient catalysts for the three-component coupling reactions of amines, alkynes and CH2Cl2

Propargylamines are key intermediates for the synthesis of many biologically active molecules. A new synthesis of propargylamines via a three component-coupling reactions of amines, alkynes and dichloromethane (AHA) using bimetallic nanoparticles Au–M (M = Cr, Cu, Co) supported on CeO2 catalysts was investigated. Bimetallic particles are regularly distributed on ceria and range in size from 8 to 11 nm. Synergetic effect between gold and the second metal was demonstrated. Different propargylamines were synthesized with high yields (60–85%) using Au–Co/CeO2 as an active heterogeneous catalyst.