Характеристика перебігу хронічного гастродуоденіту у поєднанні з первинною артеріальною гіпертензією у дітей залежно від забезпечення організму магнієм

Magnesium is one of the most common elements in the human body and its deficiency can significantly affect the pathogenesis of inflammatory changes in the gastrointestinal tract and blood circulation in the body. The purpose:  To characterize the course of combined pathology of chronic gastroduodenitis and primary arterial hypertension in children and to determine its dependence on the magnesium supply. Materials and methods.  47 children of 10–17 years old with combined course of chronic gastroduodenitis (CHD) and primary hypertension (PH) were examined. The first (I) group consisted of 27 children with a concentration of magnesium in the serum <0.8 mmol/l. The second (II) group included 20 children with a serum concentration of magnesium <0.8 mmol/l. Results.  Group II children showed more pronounced clinical manifestations, especially epigastric sensation in 80% and palpitations in 55.0% of children compared to 51.9% (p=0.047) and 25.9% (p=0.04) of children in group I, respectively. The activity rate was low in both groups, however, in patients in group II, there were worse results of the assessment of the quality of night sleep (p=0.04), as well as a tendency to lower values of indicators of well-being in comparison with the children of group I. The results of ABPM showed that the average daily SAT in children of group I was 141.1±1.7 mm Hg, in children of group II — 142.3±1.5 mm Hg. (p=0.6). The average daily DBP was 69.4±1.2 mmHg. in children of group I against 70.8±1.1 mm Hg in children of group II, (p=0.39). The non-dipper overnight reduction option was found in 44.4% of children in group I compared to 75.0% of children in group II (p=0.04). According to the results of endoscopic examination, pangastritis (p=0.02) was observed in 50% of children in group II compared to 22.2% of children in group I. Conclusion.  Children with a combined course of CHD and PHwith serum magnesium concentration less than 0.8 mmol/l were more likely to experience complaints of epigastric gravity and palpitations. They had poorer night sleep quality, as well as a higher prevalence of inflammatory process in lesions of the gastric mucosa and duodenum. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors.