Association of CDKN2B-AS1 Gene polymorphism with Acute Myocardial Infarction.

Background and objectives: Several genetic studies have demonstrated an association between genetic variants in a region on chromosome 9p21 and acute myocardial infarction. We aimed to investigate the association between the cyclin-dependent kinase inhibitor 2B antisense RNA rs1333049 single nucleotide polymorphisms on chromosome 9p21 and acute myocardial infarction, in addition to determine the association between risk genotypes and 1- year outcome in such patients. Methods: A total of 150 subjects (100 patients with acute myocardial infarction and 50 participants as a controls) were enrolled in the study. All subjects underwent genotyping of rs1333049. Patients were followed up for 1 year for development of reoccurrence of myocardial infarction, re-coronary intervention and cardiovascular death. Results: The frequency of the GC and CC genotypes of rs1333049 is higher in patients in comparison with controls (54% vs 36% and 36% vs 18% respectively, p