The Relationship Between Bispectral Index and Propofol During Target-Controlled Infusion Anesthesia: A Comparative Study Between Children and Young Adults

BACKGROUND: In this prospective study, we compared the relationship betweenpropofol concentrations and bispectral index (BIS) in children versus young adultsanesthetized with target-controlled infusion (TCI) of propofol.METHODS: Forty-five prepubertal subjects (children) and 45 postpubertal subjects(adults) were studied. All patients were anesthetized with TCI of propofol, basedon the Kataria et al.’s model for children and on the Schnider et al.’s model foradults. All data from the BIS and the TCI system were continuously recorded usingRugloop software. Remifentanil was continuously administered throughout thestudy (0.25 g kg