Principle of plotting the age distribution of persons with hereditary diseases at various ages of onset and differential mortality

: A method for ascertaining the mode of current age distributions is suggested for accurate quantitative assessment of some genetic parameters of hereditary diseases, such as age-specific penetrance, frequency of heterozygotes in the general population, fitness. The method is based on estimating the age-specific proportion of affected among the total number of heterozygotes, which seems more reasonable than the common methodology, considering the age-specific proportion of affected among all cases of the disease indicated.