Structure-activity relationships of some arylglycine analogues and catechol isosteres of BRL 36650, a 6.ALPHA.-formamido penicillin.

The catecholic acylureido derivative BRL 36650 was the most potent, especially against Pseudomonas aeruginosa strains. We now report on analogues of 1 which either retain a catechol or dihydroxyphenyl unit or contain various catechol isosteres.