Investigating Dementia via a multicompartmental poroelastic model of parenchymal tissue
2017
In this paper, a workflow within the VPH-DARE@IT Clinical Research Platform is presented. This
is used to model the biomechanical behaviour of perfused brain tissue. This workflow features a 3D
multicompartmental poroelastic framework, patient-specific brain anatomy representations and
continuous waveforms of internal carotid and vertebral arteries, which are used as a means of
personalizing the boundary conditions that feed the arterial compartment of the in-house
poroelastic solver. Results are shown comparing CSF/ISF clearance and accumulation in two males
of similar age, both are non-smokers, however one is more active and is diagnosed with MCI and
experiences less sleep.
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