New Procedure for the Preparation of the Tetrazole Analogue of GABA

Abstract The hydrochloride of the tetrazolyl bioisostere of the neurotransmitter GABA can be easily prepared by means of three simple steps: a Gabriel-type substitution on 4-bromobutyronitrile with Boc2NH, a tetrazole formation by action of azidotributyltin on the cyano group and a deprotection step using gaseous HCl.