Pharmacological and physiological specificities of local anesthesia in dentistry

: Described in the paper are the specificity of local analgesia at the medical dental procedures and the effect produced by local anesthetics and vasoconstrictive agents on the induction of nervous fibers and peripheral blood circulation. The pharmacological-and-physiological mechanisms of local analgesia by a 2% artikain solution (with adrenalin, concentration 1:100,000) and by a 2% mepivakain solution (with adrenalin, concentration 1:100,000) exerted on the pain sensitivity and blood circulation in the tooth pulp are analyzed.