Pathology and Molecular Biology

To explore the molecular biology of diffuse gastric cancer (DGC), it is important to have an overview of the molecular biology of gastric cancer (GC) in general. Recent advances in tumor genome sequencing, as well as gene expression and proteomic analysis, have allowed the distinction of new GC subtypes. We will review two major molecular classifications proposed by two different groups: The Cancer Genome Atlas and the Asian Cancer Research Group.