Total synthesis of calothrixins A and B via oxidative radical reaction of cyclohexenone with aminophenanthridinedione
2014
Abstract Bioactive indolo[3,2- j ]phenanthridine alkaloids, calothrixin B and its N -oxide derivative calothrixin A have been synthesized via an oxidative free radical reaction. Calothrixin B is generated from the commercially available 2,4,5-trimethoxybenzaldehyde in only seven steps. The key step in this synthesis is the Mn(OAc) 3 mediated oxidative free radical reaction of 9-(benzylamino)phenanthridine-7,10-dione with cyclohexenone to form 12-benzyl-12 H -indolo[3,2- j ]phenanthridine-7,13-dione.
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