Adaptogenic role of serotonin in dogs coming out of an experimental neurosis

: In a study carried out on dogs by means of alimentary salivary conditioned reflexes, it was found out that serotonin injection into the anterior limbic cortex and the action of neurogenous stimuli lead neither to the development of experimental neurosis nor to the usual for the neurosis increase of blood serotonin level. At the treatment of experimental neurosis by small doses of 5-oxytryptophan, the therapeutic effect of this serotonin predecessor appeared only in the days of its injection. In the subsequent period, the neurotic changes in the higher nervous activity continued, and the blood serotonin level remained increased. These data as well as materials earlier obtained on the increase of the blood serotonin level at neurosis in dogs, give reason to consider the increase of activity of the serotoninergic system at neurosis as one of adaptogenous factors contributing to the coming out of neurosis.