Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression.
1999
Background
The MDM2 oncogene functions as a negative feedback regulator of the p53 tumor suppressor. Abnormal expression of MDM2 in tumors may attenuate the p53-mediated growth arrest and apoptosis response, resulting in increased cell proliferation and resistance to chemotherapy.
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