Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture

Wei Luo,Yidan Wang,Lin Zhang,Pingping Ren,Chen Zhang,Yanming Li,Alon Azares,Michelle Zhang,Jiao Guo,Ketan B. Ghaghada,Zbigniew Starosolski,Kimal Rajapakshe,Cristian Coarfa,Yumei Li,Rui Chen,Keigi Fujiwara,Jun Ichi Abe,Joseph S. Coselli,Dianna M. Milewicz,Scott A. LeMaire,Ying H. Shen

Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture

2020

Background: Sporadic aortic aneurysm and dissection (AAD), caused by progressive aortic smooth muscle cell (SMC) loss and extracellular matrix degradation, is a highly lethal condition. Identifying...

Keywords:

Sting
Aortic aneurysm
Internal medicine
Extracellular Matrix Degradation
Medicine
Aortic dissection
Programmed cell death
Matrix metalloproteinase
Pathology
Dissection
Cardiology
Cell

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