Efficient Synthesis of Bifenazate
2006
Abstract The synthesis of bifenazate using a two‐step procedure has been accomplished with an overall yield of 26%. The procedure involved the Lewis acid–catalyzed electrophilic aromatic substitution of 4‐methoxybiphenyl with diisopropyl azodicarcoxylate (DIAD) to give a hydrazinedicarboxylate intermediate that was then subjected to a decarboxylation reaction to give bifenazate.
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