Type I interferon dysregulation and neurological disease.

Dysregulation of the type I interferon pathway has been implicated in the pathogenesis of a spectrum of neuroinfectious and neuroinflammatory disorders. McGlasson et al. review the range of neurological diseases associated with type I interferon underactivity and overactivity, highlighting advances in our understanding of the molecular and cellular pathogenesis of these conditions. They also discuss the potential utility of type I interferon as a biomarker and therapeutic target in neuroinflammatory disease.