CONTRIBUTIONS TO THE COORDINATION CHEMISTRY OF TECHNETIUM I. COMPLEXES OF TECHNETIUM-(I) WITH AMINO ACIDS

The radionuclide 99mTc is widely used in nuclear medical diagnostics. Radiopharmaceuticals containing coordination com~tmds labeled with ~rnTc4+ or ~mTc3+ can be rapidly prepared from pertechnetate eluted from a 99Mo]99mTc generator. For the optimization of the imaging agent it is essential to determine the exact chemical structure of the Tc complex. This can be achieved by synthesizing macroscopic amounts of the analogous long-lived 99gTc compound and by its analysis by appropriate spectroscopy methods. We have successfully synthesized and characterized new technetium complexes with amino acids and also with ligands containing nitrogen, oxygen and sulfur atoms.