Metabolites of estradiol-17β in bovine liver: Identification of the 17-β-d-glucopyranoside of estradiol-17α

Abstract An investigation of the unidentified polar metabolites from the livers of steers treated with [4- 14 -C]-estradiol-17 β or its 3-benzoate revealed them to consist principally of glycosidic derivates of estradiol-17α. The major polar metabolite was the 17-β- d -glucopyranoside of estradiol-17α. The 3-β- d -glucosiduronate of estradiol-17α, and other 17-glycosides of estradiol-17α and estradiol-17β were also characterized. This study demonstrates for the first time the presence of estrogen glycosides in bovine liver tissue.