Expression and clinical significance of galectin-8 in laryngeal squamous cell carcinoma

[Objective]To investigate the expression and clinical significance of galectin-8 in laryngeal squamous cell carcinoma(LSCC).[Methods]The expression of galectin-8 mRNA in 42 cases of LSCC and 18 cases of paraneoplastic tissues was detected by reverse transcription-polymerase chain reaction(RT-PCR),and the immunohistochemistry was performed to detect the protein level of galectin-8.The relationship between galectin-8 expression and clinical pathologic factors in LSCC was observed.[Results]The expression of galectin-8 was significantly higher in LSCC than in peri-cancer tissue both in mRNA and protein levels(P0.05).The expression of galectin-8 protein was positively correlated with the T stage,clinical stage and lymph node metastasis of patients with LSCC, but negatively correlated with grades of histopathological differentiation in LSCC.[Conclusions]Galectin-8 can play an important role in the tumorigenesis and development of LSCC,and can be a prognostic factor for clinic.