A new series of macrolide derivatives with 4″-O-saccharide substituents

Abstract A series of novel derivatives of macrolide with 4″- O -mono- or disaccharides were synthesized. The corresponding glycosyl trichloroacetimidates were used as the donors in the glycosylations. The in vitro antibacterial activities of 7a – f and 13 – 16 against a panel of susceptible and resistant pathogens were tested. The modification of 4′′- O -mono- or disaccharides may lead to the understanding of interaction of the macrolide and the bacterial ribosome.