Effects of Manidipine Hydrochloride on the Renal Microcirculation in Spontaneously Hypertensive Rats

We wished to clarify the effects of a newly developed calcium antagonist, manidipine hydrochloride (HCl), on renal microcirculation in hypertensive rats by using the micropuncture technique. Oral administration of manidipine HCl for 2 months reduced systemic blood pressure (BP), did not change the single-nephron glomerular filtration rate (SNGFR), but increased the SNG plasma low (SNGPF). Moreover, the glomerular transcapillary hydraulic pressure difference (ΔP), which is assumed to be the parameter most related to development of glomerulosclerosis, was significantly reduced