Deep Auto-encoder with Neural Response.

Artificial intelligence and neuroscience are deeply interactive. Artificial neural networks (ANNs) have been a versatile tool to study the neural representation in the ventral visual stream, and the knowledge in neuroscience in return inspires ANN models to improve performance in the task. However, how to merge these two directions into a unified model has less studied. Here, we propose a hybrid model, called deep auto-encoder with the neural response (DAE-NR), which incorporates the information from the visual cortex into ANNs to achieve better image reconstruction and higher neural representation similarity between biological and artificial neurons. Specifically, the same visual stimuli (i.e., natural images) are input to both the mice brain and DAE-NR. The DAE-NR jointly learns to map a specific layer of the encoder network to the biological neural responses in the ventral visual stream by a mapping function and to reconstruct the visual input by the decoder. Our experiments demonstrate that if and only if with the joint learning, DAE-NRs can (i) improve the performance of image reconstruction and (ii) increase the representational similarity between biological neurons and artificial neurons. The DAE-NR offers a new perspective on the integration of computer vision and visual neuroscience.