[Analysis of clinical factors that influence re-stenosis after percutaneous coronary stenting].

Course of Clinical Pharmacy, Graduate School of Pharmaceutical Science, Meiji PharmaceuticalUniversity, 25221 Noshio, Kiyose, Tokyo 2048588, Japan(Received January 5, 2007; Accepted May 21, 2007)Evidence has recently been accumulating that a sirolimus-eluting stent(DES) is superior to a bare-metal stent(BMS) in preventing restenosis after percutaneous coronary intervention(PCI), and an increasing number of Japanesehospitals have been adopting DES. We conducted a retrospective study to identify clinical factors that in‰uence the riskof restenosis after PCI, including stent types, by analyzing the data of 49 continuous patients who received PCI and fol-low-up coronary angiography in Hiratsuka City Hospital between March, 2004 and March, 2005. Age, sex, body massindex, smoking, complications, clinical diagnosis before PCI, the site and number of stenoses, implanted stent type(BMS or DES), the number of stents used, maximum in‰ating pressure and withdrawal of ticlopidine due to its adversedrug reactions were chosen as potential factors that may in‰uence the risk of restenosis, and the correlation betweenthese factors and restenosis was tested by Student'st-test or chi-square test. Coronary restenosis developed in 10 out of49 patients, and factors having signiˆcant correlation with restenosis were age(73±7 in the restenosis group(R) and 64±12 in the non-restenosis group(N)(p＜0.05)) and thetypeof stent(DES used in only one of 10 cases in R whereas in24 of 39 in N (p＜0.001)). Multivariate analysis showed older age(odds ratio(OR):1.200(95％CI: 1.0382.823))and the use of DES are independent predictors for restenosis(OR: 0.015 (95％CI: 0.0010.249)). Our study furthersupports the e‹cacy of DES in PCI, but its long-term outcome is yet to be conˆrmed.Key words―stent; percutaneous transluminal coronary angioplasty; coronary restenosis; ticlopidine; retrospectivestudy