Abstract 16798: Urinary Biomarkers at Admission in Out-of-hospital Cardiac Arrest Patients May Predict Acute Kidney Injury and Patient Outcome

Introduction: Urine biomarkers may be used to diagnose acute kidney injury (AKI) and predict patient outcome. Hypothesis: Urinary AKI biomarkers sampled at admission after out-of-hospital cardiac arrest (OHCA) may predict AKI, mortality and unfavourable neurological outcome (UNO). Methods: Prospective observational study of resuscitated, comatose OHCA patients treated with targeted temperature management to 33°C for 24 hours at Oslo University Hospital Ulleval, Oslo, Norway. AKI was diagnosed during the first three days based on the Kidney Disease Improving Global Outcomes (KDIGO) guidelines. UNO defined as cerebral performance category 3-5 and mortality were assessed after six months. Urine samples were collected at hospital admission and analyzed for cystatin C, neutrophil gelatinase-associated lipocalin (NGAL) and the NephroCheck™ test calculating the product of tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP-7). Data are compared using the Mann-...