SOME WAYS OF CORRECTION OF GASTRO- AND NEPHROPATHY CAUSED BY THE ADMISSION OF NONSTEROID ANTI-INFLAMMATORY AGENTS

Рurpose.To study in comparative aspect the effectiveness of certain i-ACE (Angiotensin-converting enzyme inhibitors), omeprazole and misoprostol on the frequency of ulcerative-erosive lesions of the gastric mucosa and kidney damage when used together with indomethacin. Materials and methods. Studies were carried out on 144 healthy white male rats of a mixed population with a body weight of 160-200 g at the beginning of the experiment. Animals were kept on a standard diet of vivarium. The studies were carried out in accordance with the European Convention for the Protection of Vertebrate Animals Used for Experiments or for Other Scientific Purposes ETS N 123. According to the Helsinki Declaration on the Humane Treatment of Animals, simultaneous decapitation was performed as part of the rules of euthanasia. There were 12 studied groups and each group consisted of 6 animals. We studied the anti-ulcerogenic effect of enalapril, lisinopril, captopril, omeprazole and misoprostol when they are co-administered with indomethacin at 5 and 10 days of administration. Also in these terms, the frequency and area of erosive and ulcerative lesions of the stomach were studied with the combined use of indomethacin with omeprazole and enalapril, with omeprazole and lisinopril, with omeprazole and captopril, with omeprazole and misoprostol. In the same periods the damaging effects of indomethacin on the kidneys were evaluated. Results. With the introduction of indomethacin at a dose of 2.5 mg / kg for 5 days in 100% of animals, erosive and ulcerative lesions of the gastric mucosa occur. These changes were also observed in 10-day use of the drug. With the combined use of indomethacin with enalapril in a 5-day period, the frequency of erosive-ulcerative lesions remained the same, and with 10-day administration, there was an observation of mucosal damage only in 66.6% of the animals. With the combined administration of indomethacin with lisinopril, a more significant effect of the drug was observed. The best in terms of prophylactic use were captopril and misoprostol. With a 5-day administration of indomethacin, the protein content in the urine increases by almost 5 times, AlAT (alanine aminotransferase) and AsAT (aspartate transaminase) to more than 3 times. With a 10-day administration, these changes are exacerbated. The protein content increases by almost 6 times, and AlAT and AsAt are 5 times that of the control group. In the treatment of i-ACE, a positive effect of the drugs on the indicators of protein and fermentation was noted. The best results were observed in the group treated with captopril. Omeprazole has practically no effect on protein and fermentation indices with indomethacin nephropathy. Misoprostol has an almost similar nephroprotective effect as captopril. With the joint use of ACE-inhibitors, omeprazole and misoprostol with indomethacin, the damaging effect of indomethacin on the gastric mucosa is reduced. In this plan, the most effective of ACE-inhibitors is captopril. While the combined use of ACE-inhibitors with omeprazole and misoprostol with omeprazole, the efficacy of drugs increases. In terms of correcting the side effects of indomethacin on the mucosa of the gastroduodenal zone, the combined use of omeprazole with captopril or misoprostol is considered to be the most appropriate. I-ACE and misoprostol have a renoprotective effect in indomethacin nephropathy. Omeprazole does not affect the performance of protein and fermentation. Captopril and misoprostol have the best renoprotective effect. With the combined use of i-ACE and misoprostol with omeprazole, their renoprotective effect does not change.