Analysis the correlation factor between perinatal pregnancy infection and neonatal infection

Objective To evaluate the relationship between maternal perinatal infection and early-onset neonatal infection,in order to prevention and cure neonatal perinatal infection and decrease the death rate.Methods A case-control clinical study of 238 neonates(gestational age 32~42 weeks)was conducted including 118 newborns with a variety of materna1 perinatal infection items(with at least one item of:premature rapture of membrane last for the same as or more than 24 h,chorioamnionitis,maternal antepartum fever more than 37.5 ℃,peripheral white blood cell and neutrophil count or the peripheral blood CRP level increased,positive blood culture) and 120 neonates without those items.CRP level in peripheral blood was measured and the clinical information about neonates and their mothers were recorded and analyzed.Results The incidences of CRP anomalies(16.7%)and early-onset septicaemia(9.3%) in disease group were higher than those in control group(6.7%,1.7%),and the differences were statistically significant(χ2=6.060,P0.05;χ2=5.962,P0.05).The neonates whose mother was infected with CRP anomalies during perinatal stage,the incidence of CRP anomalies and early-onset septicaemia was 30.2% and 15.9%,respectively.Maternal antepartum fever was the highest risk(86.7%) which could lead to the CRP anomalies in neonates,and also the morbidity of septicaemia was the highest(73.3%).Conclusions Perinatal infection highly suggests the possibility of neonatal infection and the detection of infectious indexes should be enhanced during perinatal stage.Peripheral blood CRP can reflect the possibility of neonatal infection.It is very important to dynamic monitoring CRP in prevention the early neonatal infection.