PRELIMIARY PHYTOCHEMICAL SCREEIG AD ATI DIABETIC ACTIVITYOF ROOTS MAGIFERA IDICA LI .

Summary Mangifera indica Linn (Anacardiaceae) is well known for curing a variety of ailments such as abscesses, broken horn, tumour, snakebite, stings, datura poisoning, heat stroke, anthrax, blisters and wounds in the mouths. The present study was to evaluate the preliminary phytochemical screening and antidiabetic activity of aqueous & alcoholic extract of Mangifera indica Linn root in alloxan;induced diabetic rats. Albino rats were rendered diabetic by alloxan (150 mg/kg, intraperitoneally). The aqueous and ethanolic extracts were orally administered to diabetic rats at 200 and 400 mg/kg doses daily for 15 days to determine antidiabetic activity. The phytochemical screening of alcoholic and aqueous extracts shows the presence of carbohydrates, glycoside, phenolic compounds, tannin and flavonoids. The fasting blood glucose level decreases by 29.5, 58.9 % (aqueous extract) and 38.8, 48.1 % (ethanolic extract) after 15 th day in diabetic rats treated with a different doses of 200 mg and 400 mg/kg body weight respectively. In conclusion, the present study using biochemical assays pertaining to blood glucose level of different animal models reveals that aqueous and alcoholic extract of root of Mangifera indica has moderate hypoglycemic and antidiabetic potential.