30EMF COVID-19 Infection Experiences and Social Determinants of Health in North Carolina: A Qualitative Analysis

Study Objectives: Social determinants of health (SDOH) influence the health outcomes of COVID-19 patients;yet, little is known about how patients at risk of significant disease burden view this relationship. Our study sought to explore patient perceptions of the influence of SDOH on their COVID-19 infection experience and COVID-19 transmission within their communities. Methods: We conducted a qualitative study of patients in a North Carolina health care system’s registry who tested positive for COVID-19 from March 2020 through February 2021. All patients’ addresses across six counties served were geo-referenced and analyzed by Kernel Density Estimation (KDE) to identify population-dense outbreaks of COVID-19 (hotspots). Spatial autocorrelation analysis was performed to identify census area clusters of white, Black and Hispanic populations, based on the 2019 American Community Survey dataset. Patients were identified by a randomized computer-generated sampling method. Patients participated in semi-structured phone interviews in English or Spanish based on patient preference by trained bilingual researchers. Each interview was evaluated using a combination of deductive and inductive content analysis to determine prevalent themes related to COVID-19 knowledge and diagnosis, disease experience, and the impact of SDOH. Results: The 10 patients interviewed from our COVID-19 hotspots were of equal distribution by sex, and predominantly Black (70%), ages 22-70 years (IQR 45-62 years), and presented to the ED for evaluation (70%). The respondents were more frequently publicly insured (50% medicaid/medicare;vs 30% uninsured;vs 20% private). The interviews demonstrated themes surrounding the experience and impact of COVID-19. The perceived risk of contracting COVID-19 and knowledge of how to prevent infection varied greatly and could be in part explained by SDOH such as their occupation and living conditions. The experiences of COVID-19 testing, diagnosis, isolation and treatment were most influenced by the timing of infection in relation to the study period. Earlier in the pandemic, the knowledge of isolation requirements and available support systems seemed to have negatively impacted the ability to isolate and follow public health guidance, as well as the support mechanisms provided by employers during this period. Communication of infection status once diagnosed varied greatly, with some voicing feelings of shame, and others advocating for sharing of infection experiences to change community behaviors. Suggestions for how to improve the COVID-19 response included improving communication and enforcing public health guidelines, including raising awareness for vulnerable populations. Conclusion: Further exploration of important themes and related SDOH that influenced how the participants experienced the COVID-19 pandemic will be necessary to decrease the negative impacts of SDOH in communities that are high-risk for COVID-19 spread.