Oxazinopteridinas and N-substituted oxazinopteridinonas

A compound of Formula 1 ** ** Formula or a pharmaceutically acceptable salt thereof, wherein: G1 is selected from N and CR7; G2 is selected from C> = O and CH2; Ar is selected from C 6-14 aryl and C 1-10 heteroaryl; m is 0, 1, 2, 3 or 4; n is 0,1, 2 or 3; each R1 is independently selected from cyano, halo, hydroxy, nitro, oxo, C1-6 alkyl optionally substituted C1-4alkoxy, optionally substituted C2-4alkenyl, optionally substituted C2-4 alkynyl, optionally substituted C3-8 cycloalkyl optionally substituted , C3-6 heterocyclyl, optionally substituted C6-14 aryl, optionally substituted C6-14 aryloxy, optionally substituted C1-10 heteroaryl, optionally substituted heteroaryloxy optionally substituted C1-10, -C (O) OR4, -OC (O) R4, -N (R4) R5, -NHC (O) N (R8) R9, -S (O) 2R6, - S (O) 2N (R4) R5, -C (O) N (R8) R9, -NHC ( O) OR 10, -NHS (O) 2NHR8, -NHS (O) 2R6, -NHC (O) NHN (R8) R9, -NHC (S) N (R8) R9, - NHC (> = NR11) N (R8 ) R9, -NHC (SR12) N (R8) R9 and NHC (> = NR11) OR13; R2 is selected from hydrogen, cyano, halo, hydroxy, nitro, C1-6 alkyl optionally substituted C1-4alkoxy, optionally substituted C2-4alkenyl, optionally substituted C2-4 alkynyl, optionally substituted C3-6 heterocyclyl, optionally substituted aryl C6-14 optionally substituted C6-14 aryloxy, optionally substituted C1-10 heteroaryl, optionally substituted -C (O) OR4, -OC (O) R4, -N (R4) R5 and -S (O) 2R6; R3 is selected from hydrogen, optionally substituted C1-6 alkyl, C3-8 cycloalkyl optionally substituted C3-6 heterocyclyl, optionally substituted C6-14 aryl, optionally substituted C1-10 heteroaryl, optionally substituted - (CH2) nN (R4) R5 , - (CH2) nC (O) N (R4) R5 and -S (O) 2R6; each R4 and R5 is independently selected from 25 hydrogen, optionally substituted C1-6 alkyl, C3-8 cycloalkyl, optionally substituted phenyl, optionally substituted C3-6 heterocyclyl C1-10 optionally substituted and heteroaryl optionally substituted; each R6 is independently selected from optionally substituted C1-6 alkyl, C3-8 cycloalkyl, optionally substituted phenyl, optionally substituted C3-6 heterocyclyl, optionally substituted heteroaryl and optionally substituted C1- 10; R7 is selected from hydrogen, cyano, halo, hydroxy, nitro, C1-4 alkyl optionally substituted, optionally substituted C1-4 alkoxy, -C (O) OR4, -C (O) N (R4) R5, -N (R4 ) R5, -NHC (O) R4, -NHC (O) N (R4) R5, -OC (O) N (R4) R5, - NHC (O) OR6, -S (O) 2R6, -NHS (O ) 2R6 and -S (O) 2N (R4) R5; each R8 and R9 are independently selected from hydrogen, optionally substituted C1-6 alkyl, C3-8 cycloalkyl, optionally substituted C6-14 aryl, optionally substituted C3-6 heterocyclyl C1-10 optionally substituted and heteroaryl optionally substituted; each R10 is independently selected from C1-6 alkyl optionally substituted C3-8 cycloalkyl, optionally substituted C6-14 aryl, optionally substituted C3-6 heterocyclyl C1-10 optionally substituted and heteroaryl optionally substituted; each R11 is independently selected from hydrogen, cyano, nitro, C1-6 alkyl optionally substituted, optionally substituted C1-4 alkoxy, C3-8 cycloalkyl optionally substituted C3-6 heterocyclyl, optionally substituted C 6-14 aryl optionally substituted and heteroaryl C1- 10 optionally substituted; each R12 is independently selected from optionally substituted C1-6 alkyl and optionally substituted phenyl; each R13 is independently selected from optionally substituted C1-6 alkyl, C3-8 cycloalkyl and optionally substituted C 6-14 aryl optionally substituted; each R14 and R15 is independently selected from hydrogen, C1-6alkyl, C3-8cycloalkyl, optionally substituted phenyl, C3-6 heterocyclyl and C 1-10 heteroaryl; and each R16 is independently selected from C1-6alkyl, C3-8cycloalkyl, optionally substituted phenyl, C3-6 heterocyclyl and C 1-10 heteroaryl; wherein: each optionally substituted C1-6 alkyl is independently substituted with 0-7 substituents independently selected from cyano, halo, hydroxy, oxo, C1-4 alkyl optionally substituted, C1-4alkoxy, C2-4alkenyl, cycloalkyl C3- 8 optionally substituted C3-6 heterocyclyl, optionally substituted C1-10 heteroaryl, optionally substituted phenyl, optionally substituted C6-14 aryloxy optionally substituted, -SR 14, -C (O) OR14, -N (R14) R1555, - C (O ) N (R14) R15 and -S (O) 2R16; each optionally substituted C1-4 alkoxy is independently substituted with 0 to 6 substituents independently selected from cyano, halo, hydroxy, oxo, C2-4 alkenyl, C1-4 alkoxy, optionally substituted C3-8 cycloalkyl, optionally substituted C1-10 heteroaryl, optionally substituted phenyl, -C (O) N (R14) R15 and -C (O) OR14; C2-4 alkyl optionally substituted each is independently substituted with 0 to 3 substituents independently selected from cyano, halo, hydroxy, oxo, C1-4 alkoxy, C3-8 cycloalkyl, C1-10 optionally substituted heteroaryl, optionally substituted phenyl, -C ( O) N (R14) R15 and -C (O) OR14; C2-4 alkynyl each optionally substituted is independently substituted with 0 to 3 substituents independently selected from cyano, halo, hydroxy, oxo, C1-4 alkoxy, C3-8 cycloalkyl, optionally substituted C1-10 heteroaryl, optionally substituted phenyl, -C ( O) N (R14) R15 and -C (O) OR14; each optionally substituted C3-8 cycloalkyl is independently substituted with 0 to 6 substituents independently selected from cyano, halo, hydroxy, nitro, oxo, C1-4 alkyl optionally substituted C1-4 alkoxy, C2-4 alkenyl, C3-8 cycloalkyl, C3-8 cycloalkoxy, optionally substituted C1-10 heteroaryl, optionally substituted phenyl, -C (O) N (R14) R15, -C (O) N (R14) R15, -N (R14) R15, -NHC (O) R14, -NHC (O) OR14 and -C (O) OR14; each optionally substituted C1-10 heteroaryl is independently substituted with 0 to 5 substituents independently selected from cyano, halo, hydroxy, oxo, nitro, C1-4 alkyl optionally substituted C1-4 alkoxy, C3-8 cycloalkyl, C3-6 heterocyclyl optionally substituted C1-10 heteroaryl, optionally substituted phenyl, - C (O) N (R14) R15, -N (R14) R15, -C (O) N (R14) R15, -OC (O) NR14R15, -NHC ( O) OR 16, -NHS (O) 2R16, -S (O) 2N (R14) R15, - NHC (O) N (R14) R15, -C (O) OR14 and -S (O) 2R16; each optionally substituted C1-10 heteroaryloxy is independently substituted with 0 to 5 substituents independently selected from cyano, halo, hydroxy, nitro, oxo, C1-4 alkyl optionally substituted, C1-4 alkoxy, trifluoromethyl, optionally substituted phenyl and -S (O ) 2R16; each optionally substituted C3-6 heterocyclyl is independently substituted with 0 to 4 substituents independently selected from cyano, halo, hydroxy, nitro, oxo, C1-4 alkyl optionally substituted C1-4alkoxy, optionally substituted C2-4alkenyl, cycloalkyl C3- 8 optionally substituted C3-8 cycloalkoxy, C3-6 heterocyclyl, C1-10 heteroaryl, optionally substituted phenyl, -C (O) N (R14) R15, -C (O) N (R14) R15, -N (R14) R15 and -C (O) OR1425; each optionally substituted C1-4 alkyl is independently substituted with 0 to 5 substituents independently selected from cyano, halo, hydroxy, nitro, oxo, C1-4 alkoxy optionally substituted C2-4alkenyl, C3-8 cycloalkyl, C3-8 cycloalkoxy, C3-6 heterocyclyl, C1-10 heteroaryl, phenyl, -SR 14, -C (O) N (R14) R15 -N (R14) R15 - C (O) OR14 and -S (O) 2R16; each optionally substituted C6-14 aryl is independently substituted with 0 to 5 substituents independently selected from cyano, halo, hydroxy, nitro, oxo, C1-4 alkyl optionally substituted, C1-4alkoxy, C2-4alkenyl, C1-10heteroaryl, trifluoromethyl, trifluoromethoxy, -N (R14) R15, -C (O) N (R14) R15, -OC (O) N (R14) R15, -NHC (O) OR16, - NHS (O) 2R16, -S ( O) 2N (R14) R15, -NHC (O) N (R14) R15, -C (O) OR14 and -S (O) 2R16; each optionally substituted C6-14 aryloxy is independently substituted with 0 to 5 substituents independently selected from cyano, halo, hydroxy, nitro, oxo, C1-4 alkyl optionally substituted C1-4 alkoxy, C2-4 alkenyl, trifluoromethyl, trifluoromethoxy, - N (R14) R15, -C (O) N (R14) R15, -OC (O) N (R14) R15, -NHC (O) OR16, -NHS (O) 2R16, - S (O) 2N (R14 ) R15, -NHC (O) N (R14) R15, -C (O) OR14 and -S (O) 2R16; each optionally substituted phenyl is independently substituted with 0 to 5 substituents independently selected from cyano, halo, hydroxy, nitro, C1-4 alkyl optionally substituted C1-4 alkoxy, C2-4 alkenyl, C1-10 heteroaryl, trifluoromethyl, trifluoromethoxy, - N (R14) R15, -C (O) N (R14) R15, -OC (O) N (R14) R15, -NHC (O) OR16, -N HS (O) 2R16, -S (O) 2N ( R14) R15, -NHC (O) N (R14) R15, -C (O) OR14 and -S (O) 2R16; each heteroaryl moieties and heteroaryloxy as mentioned above has independently one to four heteroatoms in the ring independently selected from N, O and S, and each of the heterocyclyl moieties mentioned above is independently saturated or partially unsaturated and having one or two heteroatoms in the ring independently selected from N, O and S; and provided that the compound of Formula 1 is not 1-methyl-3- (4- (6-oxo-5- (tetrahydro-2H-pyran-4-yl) -5,6,6a, 7,9,10- hexahydro- [1,4] oxazino [3,4-h] pteridin-2-yl) phenyl) urea.