Niveles séricos de lipoproteína (a) en pacientes post infarto de miocardio

La Lipoproteina (a) [Lp(a)] es un factor de riesgoindependiente para enfermedad cardiovascular.En nuestra poblacion se desconoce el comportamiento de esta lipoproteina en los individuos post infarto de miocardio, por lo que el objetivo del presentetrabajo fue determinar las concentraciones sericas de Lp(a) en pacientes post IM. Materiales y metodos: Se realizo un estudio clinico, analitico y transversal en un totalde 105 pacientes con signos y sintomas de infarto de miocardio (70 hombres y 35 mujeres) >18 anos quienes acudieron a la emergencia del Hospital General del Sur a los cuales se les confirmo dicho diagnostico mediante estudio enzimatico y electrocardiografico y 101 individuos voluntarios clinicamente sanos del personal administrativode la Universidad del Zulia, sin cardiopatia isquemica y caracteristicas para edad, sexo, raza y habitos psicobiologicossemejantes a la muestra estudiada. A todos los individuos se les cuantifico el nivel de glucosa en ayuno, perfil lipidico y Lp(a) en suero 9 meses despues del IM. Resultados: Los niveles de Lp(a) de los pacientes infartados fueron significativamente (P 18 years who attend the emergency department of Southern General Hospital by signs and symptoms of myocardial infarction (confirmed by 12-D EKG and enzymes testing) and 101 clinically healthy human volunteers’ from the administrativestaff of the University of Zulia, without ischemic heart disease with similar age, sex, race and psychobiological of the study sample. Lp(a) determination was achieved using a commercial ELISA kit and fasting plasma glucose and lipid profile were determine by enzymatic-colorimetric assay.Results. The levels of Lp(a) in patients with prior IMAbstractSerum lipoprotein (a) in patients post myocardial infarctionRevista Latinoamericana de Hipertension. Vol. 7 - No 1, 201214were significantly (P <0.001) higher than the control subjects(56.6 mg/dL vs. 21.8 mg/dL). The RR level increased for a Lp (a) ≥ 25 mg/dL was maintained between 2.4 and 2.6. The OR showed a progressive and directly proportionalincrease with of Lp(a) levels being more significant when Lp(a) concentration was above 40 mg/dL with a OR of 9.7. Glucose levels (168.5 ± 9.3 mg/dL, p <0.001) were significantly higher than the control group. Conclusion: In patients who had a prior myocardial infarction, levels of Lp (a) were significantly higher than healthy control individuals.