Dissolution Kinetics of Certain Crystalline Forms of Prednisolone

The activity, dissolution rate, and crystal behavior of three crystalline forms of prednisolone, each exhibiting distinctly different properties, have been investigated. By determining the relative dissolution rates of the crystal forms under different agitation conditions, it was found that dissolution could be described by consecutive processes involving a reaction at the interface and transport away from the interface. The data suggested that these processes pose a double barrier to dissolution under the experimental conditions.