Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease

Reelin is crucial for brain development and controls neurogenesis and synaptic plasticity in the adult brain. Here, Pujadas et al. reveal that Reelin slows the onset of Alzheimer’s disease in a mouse model by delaying the formation of amyloid fibrils and preventing neuronal loss and cognitive decline.