Design of an Antibiotic Delivery System Based on a Bioresorbable Bone Substitute

In the current study a new composite material comprising calcium sulphate, calcium carbonate, and tripalmitin was developed as a bioresorbable drug carrier for the local antibiotic therapy. Device fabrication can be simply performed by compression moulding of the components. The evaluated bone substitute material based on a calcium sulphate/ calcium carbonate composite exhibits an excellent biocompatibility and a therapeutically useful release profile. It, therefore, represents a promising new antibiotic delivery system for the efficient prevention and treatment of bone infections.