Synthetic and biological studies on the spiro-mamakone system
2008
An exploration of the chemistry of the spiro-mamakone system, exemplified by the cytotoxic, fungal metabolitespiro-mamakone A, is presented. The first reported synthesis of the spiro-mamakone carbon skeleton was achieved, as well as the synthesis of a variety of closely related analogues of the natural product. Biological testing of the synthetic analogues generated a structure–activity profile for the natural product, establishing the importance of the enedione moiety to biological activity.
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