Long-acting sustained-release pellet and preparation method thereof

The invention discloses a long-acting sustained-release pellet and a preparation method thereof. The long-acting trimetazidine hydrochloride sustained-release pellet comprises a drug-containing core and a sustained-release coating layer from inside to outside sequentially, wherein an optional isolation coating layer is arranged between the drug-containing core and the sustained-release coating layer; the isolation coating layer accounts for 0-15 percent of the mass of the drug-containing core, and the sustained-release coating layer accounts for 5-30 percent of the mass of the drug-containing core; a gastrointestinal adhesive is contained in the sustained-release coating layer. According to the trimetazidine hydrochloride sustained-release pellet, the prescription is meticulously designed, the drug-containing core is uniformly coated by utilizing the sustained-release coating material, so that slow and uniform drug release of the drug-containing core can be maintained, the active component releasing speed can be reduced, the time for reaching the peak can be postponed, the pellet can be constantly and stably released in 24 hours, the blood concentration stability can be maintained, and the phenomenon of insufficient blood concentration in morning ischemia can be avoided. The administration frequency can be reduced to once a day, and the compliance of patients can be improved.