Multicenter, Randomized, Phase III Trial of Neoadjuvant Chemoradiation With Capecitabine and Irinotecan Guided by UGT1A1 Status in Patients With Locally Advanced Rectal Cancer

Ji Zhu,Anwen Liu,Xinchen Sun,Luying Liu,Yaqun Zhu,Tao Zhang,Jianhui Jia,Shisheng Tan,Junxin Wu,Xin Wang,Juying Zhou,Jialin Yang,Chen Zhang,Hongyan Zhang,Yuanyuan Zhao,Gang Cai,Wei Zhang,F. Xia,Juefeng Wan,Hui Zhang,Lijun Shen,Sanjun Cai,Zhen Zhang

Multicenter, Randomized, Phase III Trial of Neoadjuvant Chemoradiation With Capecitabine and Irinotecan Guided by UGT1A1 Status in Patients With Locally Advanced Rectal Cancer

2020

PURPOSEDifferentiating the irinotecan dose on the basis of the uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotype improves the pathologic complete response (pCR) rate. In this study,...

Keywords:

Capecitabine
Glucuronosyltransferase
Medicine
locally advanced
Genotype
Internal medicine
Colorectal cancer
Oncology
in patient
Uridine diphosphate
Irinotecan

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