Natural history andendocrine findings

history ofoestrogen intake throughdrugs, ointments, orfood;nosignsofoestrogensecretingtumours;noevidenceof true precocious puberty detected by luteinisinghormone releasing hormone test (namely, peakvalues of luteinising hormone greater than15 mU/ml, according to our laboratory).Of these 52 patients, three subsequently de-veloped true precocious puberty and